| Transactions |
| Date | Team | Player | Type | OthTm | EffDate | When |
| 3/29/2025 | LFK | Crews | Demoted to reserve roster | | | Before |
| 3/29/2025 | LFK | Waldron | Promoted to active roster | | | Before |
| 3/29/2025 | MIL | Hill,D | Demoted to reserve roster | | | Before |
| 3/29/2025 | MIL | Nido | Promoted to active roster | | | Before |
| 3/29/2025 | MPS | Chafin | Promoted to active roster | | | Before |
| 3/29/2025 | MPS | Freeman,T | Demoted to reserve roster | | | Before |
| 3/30/2025 | DAY | Perez,M | Demoted to reserve roster | | | Before |
| 3/30/2025 | DAY | Perez,M | Promoted to active roster | | | Before |
| 3/30/2025 | DAY | Rojas,Joh | Demoted to reserve roster | | | Before |
| 3/30/2025 | DAY | Wade,T | Promoted to active roster | | | Before |
| 3/30/2025 | MIL | Hill,D | Promoted to active roster | | | Before |
| 3/30/2025 | MIL | Nido | Demoted to reserve roster | | | Before |
| 3/30/2025 | PIP | Larnach | Placed on Injured List | | 3/30/2025 | Before |
| 3/30/2025 | PIP | Thomas,A | Promoted to active roster | | | Before |
| 3/31/2025 | BAB | Nelson,R | Promoted to active roster | | | Before |
| 3/31/2025 | BAB | Taillon | Placed on Injured List | | 3/31/2025 | Before |
| 3/31/2025 | CB | Abbott | Placed on Injured List | | 3/31/2025 | Before |
| 3/31/2025 | CB | Armstrong | Promoted to active roster | | | Before |
| 3/31/2025 | DAY | Basso | Placed on Injured List | | 3/31/2025 | Before |
| 3/31/2025 | DAY | Kelly,Z | Promoted to active roster | | | Before |
| 3/31/2025 | SAV | McKinstry | Demoted to reserve roster | | | Before |
| 3/31/2025 | SAV | Wilson,B | Promoted to active roster | | | Before |
| 4/1/2025 | FIN | Criswell,C | Promoted to active roster | | | Before |
| 4/1/2025 | FIN | Quantrill | Placed on Injured List | | 4/1/2025 | Before |
| 4/1/2025 | MNT | Miller,E | Placed on Injured List | | 4/1/2025 | Before |
| 4/1/2025 | MNT | Rogers,Tr | Promoted to active roster | | | Before |
| 4/2/2025 | LE | Bednar | Released | | | Before |
| 4/2/2025 | LE | Rice | Signed | | | Before |
| 4/3/2025 | BIW | Nola | Placed on Injured List | | 4/3/2025 | Before |
| 4/3/2025 | BIW | Verlander | Promoted to active roster | | | Before |
| 4/3/2025 | DAY | Rojas,Joh | Promoted to active roster | | | Before |
| 4/3/2025 | DAY | Wade,T | Demoted to reserve roster | | | Before |
| 4/5/2025 | BIW | Baldwin | Signed | | | Before |
| 4/5/2025 | BIW | Matz | Released | | | Before |
| 4/5/2025 | MPS | Chafin | Demoted to reserve roster | | | Before |
| 4/5/2025 | MPS | Freeman,T | Promoted to active roster | | | Before |
| 4/5/2025 | WAN | Suwinski | Promoted to active roster | | | Before |
| 4/5/2025 | WAN | Urias,L | Placed on Injured List | | 4/5/2025 | Before |
| 4/6/2025 | LFK | Crews | Promoted to active roster | | | Before |
| 4/6/2025 | LFK | Waldron | Demoted to reserve roster | | | Before |
| 4/6/2025 | WAN | Chargois | Placed on Injured List | | 4/6/2025 | Before |
| 4/6/2025 | WAN | Soroka | Promoted to active roster | | | Before |
| 4/7/2025 | COO | Feltner | Promoted to active roster | | | Before |
| 4/7/2025 | COO | Sears | Placed on Injured List | | 4/7/2025 | Before |
| 4/7/2025 | MAR | Jimenez,E | Promoted to active roster | | | Before |
| 4/7/2025 | MAR | Solano | Placed on Injured List | | 4/7/2025 | Before |
| 4/7/2025 | NH | Baz | Placed on Injured List | | 4/7/2025 | Before |
| 4/7/2025 | NH | Blackburn | Promoted to active roster | | | Before |
| 4/8/2025 | BIW | Goodman | Promoted to active roster | | | Before |
| 4/8/2025 | BIW | Wilson,Ja | Demoted to reserve roster | | | Before |
| 4/8/2025 | SAV | McKinstry | Promoted to active roster | | | Before |
| 4/8/2025 | SAV | Wilson,B | Demoted to reserve roster | | | Before |
| 4/9/2025 | WAN | Meadows | Placed on Injured List | | 4/9/2025 | Before |
| 4/9/2025 | WAN | Rocchio | Promoted to active roster | | | Before |
| 4/10/2025 | ALP | Imanaga | Placed on Injured List | | 4/10/2025 | Before |
| 4/10/2025 | ALP | Megill,Ty | Promoted to active roster | | | Before |
| 4/10/2025 | BIW | Dana | Released | | | Before |
| 4/10/2025 | BIW | Paris | Signed | | | Before |
| 4/11/2025 | BIW | Goodman | Demoted to reserve roster | | | Before |
| 4/11/2025 | BIW | Wilson,Ja | Promoted to active roster | | | Before |
| 4/11/2025 | CB | Friedl | Promoted to active roster | | | Before |
| 4/11/2025 | CB | Vierling | Placed on Injured List | | 4/11/2025 | Before |
| 4/11/2025 | GV | Jansen,D | Promoted to active roster | | | Before |
| 4/11/2025 | GV | Story | Demoted to reserve roster | | | Before |
| 4/11/2025 | ROL | Mize | Placed on Injured List | | 4/11/2025 | Before |
| 4/11/2025 | ROL | Morel | Released | | | Before |
| 4/11/2025 | ROL | Sammons | Signed | | | Before |
| 4/12/2025 | MAR | Alvarez,Y | Placed on Injured List | | 4/12/2025 | Before |
| 4/12/2025 | MAR | Trevino | Promoted to active roster | | | Before |
| 4/13/2025 | CB | Ahmed | Promoted to active roster | | | Before |
| 4/13/2025 | CB | Turner,J | Placed on Injured List | | 4/13/2025 | Before |
| 4/13/2025 | MIL | Correa | Placed on Injured List | | 4/13/2025 | Before |
| 4/13/2025 | MIL | Fairchild | Promoted to active roster | | | Before |
| 4/13/2025 | MIL | Liberatore | Demoted to reserve roster | | | Before |
| 4/13/2025 | MIL | Sewald | Promoted to active roster | | | Before |
| 4/13/2025 | NP | De La Cruz,E | Placed on Injured List | | 4/13/2025 | Before |
| 4/13/2025 | NP | Norby | Promoted to active roster | | | Before |
| 4/14/2025 | WAN | Chivilli | Promoted to active roster | | | Before |
| 4/14/2025 | WAN | Miller,Br | Placed on Injured List | | 4/14/2025 | Before |
| 4/15/2025 | BAB | Nelson,R | Demoted to reserve roster | | | Before |
| 4/15/2025 | BAB | Taillon | Activated from Injured List | | | Before |
| 4/15/2025 | CB | Abbott | Activated from Injured List | | | Before |
| 4/15/2025 | CB | Armstrong | Demoted to reserve roster | | | Before |
| 4/15/2025 | DAY | Basso | Activated from Injured List | | | Before |
| 4/15/2025 | DAY | Kelly,Z | Demoted to reserve roster | | | Before |
| 4/15/2025 | ROL | Drury | Placed on Injured List | | 4/15/2025 | Before |
| 4/15/2025 | ROL | Lee,B | Promoted to active roster | | | Before |
| 4/15/2025 | WEL | Civale | Promoted to active roster | | | Before |
| 4/15/2025 | WEL | Floro | Demoted to reserve roster | | | Before |
| 4/16/2025 | FIN | Criswell,C | Demoted to reserve roster | | | Before |
| 4/16/2025 | FIN | Quantrill | Activated from Injured List | | | Before |
| 4/16/2025 | SAV | Schwellenbach | Placed on Injured List | | 4/16/2025 | Before |
| 4/16/2025 | SAV | Wilson,B | Promoted to active roster | | | Before |
| 4/17/2025 | GV | Jansen,D | Demoted to reserve roster | | | Before |
| 4/17/2025 | GV | Story | Promoted to active roster | | | Before |
| 4/17/2025 | MNT | Miller,E | Activated from Injured List | | | Before |
| 4/17/2025 | MNT | Rogers,Tr | Demoted to reserve roster | | | Before |
| 4/17/2025 | WAN | Alexander,T | Promoted to active roster | | | Before |
| 4/17/2025 | WAN | Miller,T | Placed on Injured List | | 4/17/2025 | Before |
| 4/18/2025 | BIW | Lee,J | Promoted to active roster | | | Before |
| 4/18/2025 | BIW | Verlander | Demoted to reserve roster | | | Before |
| 4/18/2025 | EDI | Canha | Placed on Injured List | | 4/18/2025 | Before |
| 4/18/2025 | EDI | Carlson | Promoted to active roster | | | Before |
| 4/18/2025 | MNT | Miller,E | Placed on Injured List | | 4/18/2025 | Before |
| 4/18/2025 | MNT | Rogers,Tr | Promoted to active roster | | | Before |
| 4/18/2025 | SAV | Alonso | Placed on Injured List | | 4/18/2025 | Before |
| 4/18/2025 | SAV | Merrifield | Promoted to active roster | | | Before |
| 4/19/2025 | OWT | Margot | Promoted to active roster | | | Before |
| 4/19/2025 | OWT | Profar | Placed on Injured List | | 4/19/2025 | Before |
| 4/19/2025 | WAN | Meadows | Activated from Injured List | | | Before |
| 4/19/2025 | WAN | Rocchio | Demoted to reserve roster | | | Before |
| 4/20/2025 | FIN | Isbel | Promoted to active roster | | | Before |
| 4/20/2025 | FIN | Ward | Placed on Injured List | | 4/20/2025 | Before |
| 4/20/2025 | PIP | Larnach | Activated from Injured List | | | Before |
| 4/20/2025 | PIP | Thomas,A | Demoted to reserve roster | | | Before |
| 4/21/2025 | LE | Dezenzo | Released | | | Before |
| 4/21/2025 | LE | Saggese | Signed | | | Before |
| 4/21/2025 | OWT | Bassitt | Promoted to active roster | | | Before |
| 4/21/2025 | OWT | Cortes | Placed on Injured List | | 4/21/2025 | Before |
| 4/22/2025 | COO | Feltner | Demoted to reserve roster | | | Before |
| 4/22/2025 | COO | Sears | Activated from Injured List | | | Before |
| 4/22/2025 | WEL | Civale | Demoted to reserve roster | | | Before |
| 4/22/2025 | WEL | Floro | Promoted to active roster | | | Before |
| 4/24/2025 | PIP | Moore,D | Demoted to reserve roster | | | Before |
| 4/24/2025 | PIP | Morton | Promoted to active roster | | | Before |
| 4/24/2025 | WAN | Chargois | Activated from Injured List | | | Before |
| 4/24/2025 | WAN | Soroka | Demoted to reserve roster | | | Before |
| 4/25/2025 | ROL | Drury | Activated from Injured List | | | Before |
| 4/25/2025 | ROL | Lee,B | Demoted to reserve roster | | | Before |
| 4/26/2025 | WAN | Soroka | Promoted to active roster | | | Before |
| 4/26/2025 | WAN | Yarbrough | Demoted to reserve roster | | | Before |
| 4/27/2025 | BIW | Lee,J | Demoted to reserve roster | | | Before |
| 4/27/2025 | BIW | Nola | Activated from Injured List | | | Before |
| 4/27/2025 | CB | Ahmed | Demoted to reserve roster | | | Before |
| 4/27/2025 | CB | Turner,J | Activated from Injured List | | | Before |
| 4/27/2025 | WAN | Soroka | Demoted to reserve roster | | | Before |
| 4/27/2025 | WAN | Yarbrough | Promoted to active roster | | | Before |
| 4/28/2025 | CB | Friedl | Demoted to reserve roster | | | Before |
| 4/28/2025 | CB | Vierling | Activated from Injured List | | | Before |
| 4/28/2025 | GV | Machado | Placed on Injured List | | 4/28/2025 | Before |
| 4/28/2025 | GV | Urshela | Promoted to active roster | | | Before |
| 4/28/2025 | NH | Baz | Activated from Injured List | | | Before |
| 4/28/2025 | NH | Blackburn | Demoted to reserve roster | | | Before |
| 4/29/2025 | EDI | Canha | Activated from Injured List | | | Before |
| 4/29/2025 | EDI | Carlson | Demoted to reserve roster | | | Before |
| 4/29/2025 | NP | De La Cruz,E | Activated from Injured List | | | Before |
| 4/29/2025 | NP | Norby | Demoted to reserve roster | | | Before |
| 4/30/2025 | ALP | Imanaga | Activated from Injured List | | | Before |
| 4/30/2025 | ALP | Megill,Ty | Demoted to reserve roster | | | Before |
| 4/30/2025 | WAN | Suwinski | Demoted to reserve roster | | | Before |
| 4/30/2025 | WAN | Urias,L | Activated from Injured List | | | Before |
| 5/1/2025 | LE | Matos | Released | | | Before |
| 5/1/2025 | LE | Stowers | Signed | | | Before |
| 5/1/2025 | NP | Edman | Demoted to reserve roster | | | Before |
| 5/1/2025 | NP | Garver | Promoted to active roster | | | Before |
| 5/1/2025 | ROL | Mize | Activated from Injured List | | | Before |
| 5/1/2025 | ROL | Sammons | Demoted to reserve roster | | | Before |
| 5/1/2025 | SAV | Schwellenbach | Activated from Injured List | | | Before |
| 5/1/2025 | SAV | Wilson,B | Demoted to reserve roster | | | Before |
| 5/2/2025 | BIW | Cruz,F | Placed on Injured List | | 5/2/2025 | Before |
| 5/2/2025 | BIW | Lee,J | Promoted to active roster | | | Before |
| 5/2/2025 | MIL | Correa | Activated from Injured List | | | Before |
| 5/2/2025 | MIL | Fairchild | Demoted to reserve roster | | | Before |
| 5/2/2025 | NP | Edman | Promoted to active roster | | | Before |
| 5/2/2025 | NP | Garver | Demoted to reserve roster | | | Before |
| 5/2/2025 | WAN | Alexander,T | Demoted to reserve roster | | | Before |
| 5/2/2025 | WAN | Miller,Br | Activated from Injured List | | | Before |
| 5/3/2025 | MD | Honeywell | Promoted to active roster | | | Before |
| 5/3/2025 | MD | Lugo | Placed on Injured List | | 5/3/2025 | Before |
| 5/3/2025 | MNT | Miller,E | Activated from Injured List | | | Before |
| 5/3/2025 | MNT | Rogers,Tr | Demoted to reserve roster | | | Before |
| 5/3/2025 | PIP | Moore,D | Promoted to active roster | | | Before |
| 5/3/2025 | PIP | Morton | Demoted to reserve roster | | | Before |
| 5/4/2025 | BAB | Nelson,R | Promoted to active roster | | | Before |
| 5/4/2025 | BAB | Soriano,J | Placed on Injured List | | 5/4/2025 | Before |
| 5/4/2025 | LFK | Guillorme | Promoted to active roster | | | Before |
| 5/4/2025 | LFK | Massey | Placed on Injured List | | 5/4/2025 | Before |
| 5/4/2025 | SAV | Hamilton,I | Promoted to active roster | | | Before |
| 5/4/2025 | SAV | Merrifield | Demoted to reserve roster | | | Before |
| 5/5/2025 | EDI | Carlson | Promoted to active roster | | | Before |
| 5/5/2025 | EDI | Rizzo | Demoted to reserve roster | | | Before |
| 5/5/2025 | FIN | Isbel | Demoted to reserve roster | | | Before |
| 5/5/2025 | FIN | Ward | Activated from Injured List | | | Before |
| 5/6/2025 | OWT | Bassitt | Demoted to reserve roster | | | Before |
| 5/6/2025 | OWT | Cortes | Activated from Injured List | | | Before |
| 5/7/2025 | LE | Baez | Signed | | | Before |
| 5/7/2025 | LE | Barger | Released | | | Before |
| 5/7/2025 | LE | Boyle | Promoted to active roster | | | Before |
| 5/7/2025 | LE | Bride | Demoted to reserve roster | | | Before |
| 5/7/2025 | LE | Canning | Promoted to active roster | | | Before |
| 5/7/2025 | LE | Gelof | Promoted to active roster | | | Before |
| 5/7/2025 | LE | Iglesias,J | Demoted to reserve roster | | | Before |
| 5/7/2025 | LE | Uceta | Demoted to reserve roster | | | Before |
| 5/7/2025 | LE | Woo | Demoted to reserve roster | | | Before |
| 5/7/2025 | LE | Uceta | Traded away | MD | | After |
| 5/7/2025 | MAR | Povich | Promoted to active roster | | | Before |
| 5/7/2025 | MAR | Stone | Placed on Injured List | | 5/7/2025 | Before |
| 5/7/2025 | MD | Uceta | Acquired via trade | LE | | After |
| 5/7/2025 | OWT | Margot | Demoted to reserve roster | | | Before |
| 5/7/2025 | OWT | Profar | Activated from Injured List | | | Before |
| 5/8/2025 | ALP | Imanaga | Placed on Injured List | | 5/8/2025 | Before |
| 5/8/2025 | ALP | Megill,Ty | Promoted to active roster | | | Before |
| 5/8/2025 | CB | Iglesias,J | Acquired via trade | LE | | After |
| 5/8/2025 | EDI | Carlson | Demoted to reserve roster | | | Before |
| 5/8/2025 | EDI | Rizzo | Promoted to active roster | | | Before |
| 5/8/2025 | LE | Brown,B | Demoted to reserve roster | | | Before |
| 5/8/2025 | LE | Miller,S | Signed | | | Before |
| 5/8/2025 | LE | Iglesias,J | Traded away | CB | | After |
| 5/8/2025 | MD | Bernardino | Released | | | Before |
| 5/8/2025 | MD | McFarland | Demoted to reserve roster | | | Before |
| 5/8/2025 | MD | Uceta | Promoted to active roster | | | Before |
| 5/8/2025 | NP | Harrison | Demoted to reserve roster | | | Before |
| 5/8/2025 | NP | Lynn | Promoted to active roster | | | Before |
| 5/8/2025 | ROL | Gomes | Promoted to active roster | | | Before |
| 5/8/2025 | ROL | Trout | Demoted to reserve roster | | | Before |
| 5/9/2025 | CB | Canzone | Released | | | Before |
| 5/9/2025 | CB | Iglesias,J | Promoted to active roster | | | Before |
| 5/9/2025 | CB | Noel | Demoted to reserve roster | | | Before |
| 5/9/2025 | LE | Grisham | Signed | | | Before |
| 5/9/2025 | LE | Bride | Traded away | MIL | | After |
| 5/9/2025 | MIL | Bride | Acquired via trade | LE | | After |
| 5/9/2025 | ROL | Gomes | Demoted to reserve roster | | | Before |
| 5/9/2025 | ROL | Trout | Promoted to active roster | | | Before |
| 5/9/2025 | WAN | Chivilli | Demoted to reserve roster | | | Before |
| 5/9/2025 | WAN | Miller,T | Activated from Injured List | | | Before |
| 5/10/2025 | BAB | Carroll | Placed on Injured List | | 5/10/2025 | Before |
| 5/10/2025 | BAB | Farmer,K | Promoted to active roster | | | Before |
| 5/10/2025 | EDI | Cannon | Placed on Injured List | | 5/10/2025 | Before |
| 5/10/2025 | EDI | Weissert | Promoted to active roster | | | Before |
| 5/10/2025 | LE | Munoz,R | Signed | | | Before |
| 5/10/2025 | LE | Ragans | Demoted to reserve roster | | | Before |
| 5/10/2025 | MIL | Bride | Promoted to active roster | | | Before |
| 5/10/2025 | MIL | McNeil | Demoted to reserve roster | | | Before |
| 5/10/2025 | MIL | Paxton | Released | | | Before |
| 5/10/2025 | WAN | Haase | Promoted to active roster | | | Before |
| 5/10/2025 | WAN | Maldonado,M | Placed on Injured List | | 5/10/2025 | Before |
| 5/11/2025 | MAR | Alvarez,Y | Activated from Injured List | | | Before |
| 5/11/2025 | MAR | Trevino | Demoted to reserve roster | | | Before |
| 5/11/2025 | OWT | Castro,W | Placed on Injured List | | 5/11/2025 | Before |
| 5/11/2025 | OWT | Rendon | Promoted to active roster | | | Before |
| 5/12/2025 | LE | Acuna,R | Demoted to reserve roster | | | Before |
| 5/12/2025 | LE | Woo | Promoted to active roster | | | Before |
| 5/13/2025 | CB | Armstrong | Promoted to active roster | | | Before |
| 5/13/2025 | CB | Schneider | Demoted to reserve roster | | | Before |
| 5/14/2025 | GV | Brieske | Promoted to active roster | | | Before |
| 5/14/2025 | GV | Gore | Placed on Injured List | | 5/14/2025 | Before |
| 5/14/2025 | MAR | Jimenez,E | Demoted to reserve roster | | | Before |
| 5/14/2025 | MAR | Solano | Activated from Injured List | | | Before |
| 5/14/2025 | SAV | Alonso | Activated from Injured List | | | Before |
| 5/14/2025 | SAV | Schneemann | Demoted to reserve roster | | | Before |
| 5/15/2025 | LE | Ragans | Promoted to active roster | | | Before |
| 5/15/2025 | OWT | Butler | Placed on Injured List | | 5/15/2025 | Before |
| 5/15/2025 | OWT | Margot | Promoted to active roster | | | Before |
| 5/16/2025 | CB | Cecconi | Promoted to active roster | | | Before |
| 5/16/2025 | CB | Lively | Placed on Injured List | | 5/16/2025 | Before |
| 5/16/2025 | GV | Machado | Activated from Injured List | | | Before |
| 5/16/2025 | GV | Urshela | Demoted to reserve roster | | | Before |
| 5/17/2025 | BIW | Cruz,F | Activated from Injured List | | | Before |
| 5/17/2025 | BIW | Lee,J | Demoted to reserve roster | | | Before |
| 5/17/2025 | SAV | Hamilton,I | Demoted to reserve roster | | | Before |
| 5/17/2025 | SAV | Schneemann | Promoted to active roster | | | Before |
| 5/18/2025 | MD | Honeywell | Demoted to reserve roster | | | Before |
| 5/18/2025 | MD | Lugo | Activated from Injured List | | | Before |
| 5/18/2025 | MIL | Liberatore | Promoted to active roster | | | Before |
| 5/18/2025 | MIL | Sewald | Demoted to reserve roster | | | Before |
| 5/19/2025 | BAB | Nelson,R | Demoted to reserve roster | | | Before |
| 5/19/2025 | BAB | Soriano,J | Activated from Injured List | | | Before |
| 5/19/2025 | BIW | Mahle | Signed | | | Before |
| 5/19/2025 | BIW | Wagner | Released | | | Before |
| 5/19/2025 | MAR | Jimenez,E | Promoted to active roster | | | Before |
| 5/19/2025 | MAR | Raley,L | Placed on Injured List | | 5/19/2025 | Before |
| 5/19/2025 | ROL | Gomes | Promoted to active roster | | | Before |
| 5/19/2025 | ROL | Jackson,A | Placed on Injured List | | 5/19/2025 | Before |
| 5/21/2025 | MAR | Jimenez,E | Demoted to reserve roster | | | Before |
| 5/21/2025 | MAR | Sandoval | Promoted to active roster | | | Before |
| 5/21/2025 | WAN | Haase | Demoted to reserve roster | | | Before |
| 5/21/2025 | WAN | Maldonado,M | Activated from Injured List | | | Before |
| 5/22/2025 | BIW | Baldwin | Released | | | Before |
| 5/22/2025 | BIW | Benson | Signed | | | Before |
| 5/22/2025 | BIW | Candelario | Released | | | Before |
| 5/22/2025 | BIW | Martinez,A | Signed | | | Before |
| 5/22/2025 | BIW | Paris | Released | | | Before |
| 5/22/2025 | BIW | Wagner | Signed | | | Before |
| 5/22/2025 | LE | Acuna,R | Promoted to active roster | | | Before |
| 5/22/2025 | LE | Boyle | Demoted to reserve roster | | | Before |
| 5/22/2025 | LE | Woo | Demoted to reserve roster | | | Before |
| 5/23/2025 | CB | Cecconi | Demoted to reserve roster | | | Before |
| 5/23/2025 | CB | Schneider | Promoted to active roster | | | Before |
| 5/23/2025 | OWT | Castro,W | Activated from Injured List | | | Before |
| 5/23/2025 | OWT | Rendon | Demoted to reserve roster | | | Before |
| 5/24/2025 | CB | Noel | Promoted to active roster | | | Before |
| 5/24/2025 | CB | Verdugo | Placed on Injured List | | 5/24/2025 | Before |
| 5/24/2025 | LE | Boyle | Promoted to active roster | | | Before |
| 5/24/2025 | LE | Ragans | Demoted to reserve roster | | | Before |
| 5/25/2025 | MAR | Hall | Promoted to active roster | | | Before |
| 5/25/2025 | MAR | Povich | Placed on Injured List | | 5/25/2025 | Before |
| 5/26/2025 | BIW | Bradford | Placed on Injured List | | 5/26/2025 | Before |
| 5/26/2025 | BIW | Verlander | Promoted to active roster | | | Before |
| 5/26/2025 | LFK | Barnhart | Promoted to active roster | | | Before |
| 5/26/2025 | LFK | Crews | Demoted to reserve roster | | | Before |
| 5/26/2025 | LFK | Guillorme | Demoted to reserve roster | | | Before |
| 5/26/2025 | LFK | Massey | Activated from Injured List | | | Before |
| 5/27/2025 | BAB | Adams,R | Promoted to active roster | | | Before |
| 5/27/2025 | BAB | Biggio | Promoted to active roster | | | Before |
| 5/27/2025 | BAB | Kelly,Car | Placed on Injured List | | 5/27/2025 | Before |
| 5/27/2025 | BAB | Stanton | Placed on Injured List | | 5/27/2025 | Before |
| 5/27/2025 | MIL | Greene,H | Placed on Injured List | | 5/27/2025 | Before |
| 5/27/2025 | MIL | Sewald | Promoted to active roster | | | Before |
| 5/28/2025 | ALP | Imanaga | Activated from Injured List | | | Before |
| 5/28/2025 | ALP | Megill,Ty | Demoted to reserve roster | | | Before |
| 5/28/2025 | EDI | Cannon | Activated from Injured List | | | Before |
| 5/28/2025 | EDI | Weissert | Demoted to reserve roster | | | Before |
| 5/28/2025 | MAR | Jimenez,E | Promoted to active roster | | | Before |
| 5/28/2025 | MAR | Sandoval | Demoted to reserve roster | | | Before |
| 5/29/2025 | LFK | Barnhart | Demoted to reserve roster | | | Before |
| 5/29/2025 | LFK | Crews | Promoted to active roster | | | Before |
| 5/29/2025 | MIL | Liberatore | Demoted to reserve roster | | | Before |
| 5/29/2025 | MIL | Liberatore | Promoted to active roster | | | Before |
| 5/31/2025 | MAR | Casparius | Signed | | | Before |
| 5/31/2025 | MAR | Hall | Demoted to reserve roster | | | Before |
| 5/31/2025 | MAR | Smith-Shawver | Released | | | Before |
| 5/31/2025 | MAR | Stone | Activated from Injured List | | | Before |
| 5/31/2025 | MAR | Waldrep | Released | | | Before |
| 5/31/2025 | MAR | Waldrep | Signed | | | Before |
| 5/31/2025 | NP | Norby | Promoted to active roster | | | Before |
| 5/31/2025 | NP | Riley | Placed on Injured List | | 5/31/2025 | Before |
| 6/1/2025 | ALP | Beck,J | Demoted to reserve roster | | | Before |
| 6/1/2025 | ALP | Herrera,J | Promoted to active roster | | | Before |
| 6/1/2025 | CB | Armstrong | Demoted to reserve roster | | | Before |
| 6/1/2025 | CB | Lively | Activated from Injured List | | | Before |
| 6/1/2025 | LE | Alcantara | Released | | | Before |
| 6/1/2025 | LE | Narvaez,C | Signed | | | Before |
| 6/1/2025 | NH | Pham | Promoted to active roster | | | Before |
| 6/1/2025 | NH | Sanchez,J | Placed on Injured List | | 6/1/2025 | Before |
| 6/2/2025 | BIW | Goodman | Promoted to active roster | | | Before |
| 6/2/2025 | BIW | Wong | Placed on Injured List | | 6/2/2025 | Before |
| 6/2/2025 | NH | Blackburn | Promoted to active roster | | | Before |
| 6/2/2025 | NH | Santana,D | Demoted to reserve roster | | | Before |
| 6/3/2025 | NP | Flores | Signed | | | Before |
| 6/3/2025 | NP | McKenzie | Released | | | Before |
| 6/4/2025 | CB | Noel | Demoted to reserve roster | | | Before |
| 6/4/2025 | CB | Verdugo | Activated from Injured List | | | Before |
| 6/4/2025 | GV | Gore | Activated from Injured List | | | Before |
| 6/4/2025 | GV | Williams,G | Demoted to reserve roster | | | Before |
| 6/4/2025 | LE | Barger | Signed | | | Before |
| 6/4/2025 | LE | Melendez | Released | | | Before |
| 6/4/2025 | LFK | Bloss | Released | | | Before |
| 6/4/2025 | LFK | Elder | Signed | | | Before |
| 6/4/2025 | NP | Flores | Demoted to reserve roster | | | Before |
| 6/6/2025 | BIW | Bellozo | Signed | | | Before |
| 6/6/2025 | BIW | Benson | Released | | | Before |
| 6/6/2025 | BIW | Olson,R | Placed on Injured List | | 6/6/2025 | Before |
| 6/6/2025 | ROL | Gomes | Demoted to reserve roster | | | Before |
| 6/6/2025 | ROL | Jackson,A | Activated from Injured List | | | Before |
| 6/7/2025 | ALP | Beck,J | Promoted to active roster | | | Before |
| 6/7/2025 | ALP | Herrera,J | Demoted to reserve roster | | | Before |
| 6/7/2025 | ROL | Fortes | Placed on Injured List | | 6/7/2025 | Before |
| 6/7/2025 | ROL | Gomes | Promoted to active roster | | | Before |
| 6/8/2025 | BAB | Farmer,K | Demoted to reserve roster | | | Before |
| 6/8/2025 | BAB | Millas | Signed | | | Before |
| 6/8/2025 | LE | Brown,B | Promoted to active roster | | | Before |
| 6/8/2025 | LE | Kelly,Mi | Placed on Injured List | | 6/8/2025 | Before |
| 6/9/2025 | BAB | Farmer,K | Promoted to active roster | | | Before |
| 6/9/2025 | BAB | Millas | Released | | | Before |
| 6/9/2025 | BIW | Ashby | Acquired via trade | LE | | After |
| 6/9/2025 | BIW | Ragans | Acquired via trade | LE | | After |
| 6/9/2025 | BIW | Rodriguez,M | Acquired via trade | LE | | After |
| 6/9/2025 | BIW | Wilson,Ja | Traded away | LE | | After |
| 6/9/2025 | GV | Houser | Signed | | | Before |
| 6/9/2025 | GV | Warren,W | Released | | | Before |
| 6/9/2025 | LE | Ashby | Traded away | BIW | | After |
| 6/9/2025 | LE | Ragans | Traded away | BIW | | After |
| 6/9/2025 | LE | Rodriguez,M | Traded away | BIW | | After |
| 6/9/2025 | LE | Wilson,Ja | Acquired via trade | BIW | | After |
| 6/9/2025 | MAR | Povich | Activated from Injured List | | | Before |
| 6/9/2025 | MAR | Povich | Demoted to reserve roster | | | Before |
| 6/9/2025 | NH | Blackburn | Demoted to reserve roster | | | Before |
| 6/9/2025 | NH | Santana,D | Promoted to active roster | | | Before |
| 6/10/2025 | BAB | Francis | Placed on Injured List | | 6/10/2025 | Before |
| 6/10/2025 | BAB | Nelson,R | Promoted to active roster | | | Before |
| 6/10/2025 | BIW | Bellozo | Demoted to reserve roster | | | Before |
| 6/10/2025 | BIW | Bellozo | Promoted to active roster | | | Before |
| 6/10/2025 | BIW | Cruz,F | Released | | | Before |
| 6/10/2025 | BIW | Gray,Jon | Demoted to reserve roster | | | Before |
| 6/10/2025 | BIW | Martinez,A | Promoted to active roster | | | Before |
| 6/10/2025 | BIW | Ragans | Promoted to active roster | | | Before |
| 6/10/2025 | BIW | Verlander | Released | | | Before |
| 6/10/2025 | BIW | Williams,T | Traded away | MD | | After |
| 6/10/2025 | LE | Bednar | Signed | | | Before |
| 6/10/2025 | LE | Bednar | Promoted to active roster | | | Before |
| 6/10/2025 | LE | Thielbar | Signed | | | Before |
| 6/10/2025 | LE | Thielbar | Promoted to active roster | | | Before |
| 6/10/2025 | LE | Wilson,Ja | Demoted to reserve roster | | | Before |
| 6/10/2025 | MAR | Diaz,Yan | Placed on Injured List | | 6/10/2025 | Before |
| 6/10/2025 | MAR | Trevino | Promoted to active roster | | | Before |
| 6/10/2025 | MD | Williams,T | Acquired via trade | BIW | | After |
| 6/10/2025 | MPS | Casali | Promoted to active roster | | | Before |
| 6/10/2025 | MPS | Realmuto | Placed on Injured List | | 6/10/2025 | Before |
| 6/11/2025 | BAB | Carroll | Activated from Injured List | | | Before |
| 6/11/2025 | BAB | Farmer,K | Demoted to reserve roster | | | Before |
| 6/11/2025 | BIW | Avila,P | Signed | | | Before |
| 6/11/2025 | BIW | Gray,Jon | Promoted to active roster | | | Before |
| 6/11/2025 | MD | Dunning | Released | | | Before |
| 6/11/2025 | MD | Quintana | Demoted to reserve roster | | | Before |
| 6/11/2025 | NP | Norby | Demoted to reserve roster | | | Before |
| 6/11/2025 | NP | Riley | Activated from Injured List | | | Before |
| 6/12/2025 | BIW | Bradford | Activated from Injured List | | | Before |
| 6/12/2025 | BIW | Gray,Jon | Demoted to reserve roster | | | Before |
| 6/12/2025 | MIL | Grove | Promoted to active roster | | | Before |
| 6/12/2025 | MIL | Ortiz,LL | Placed on Injured List | | 6/12/2025 | Before |
| 6/13/2025 | MNT | Encarnacion | Promoted to active roster | | | Before |
| 6/13/2025 | MNT | Soderstrom | Placed on Injured List | | 6/13/2025 | Before |
| 6/14/2025 | BAB | Biggio | Demoted to reserve roster | | | Before |
| 6/14/2025 | BAB | Stanton | Activated from Injured List | | | Before |
| 6/14/2025 | BIW | Lee,J | Promoted to active roster | | | Before |
| 6/14/2025 | BIW | Refsnyder | Placed on Injured List | | 6/14/2025 | Before |
| 6/14/2025 | NH | Bello | Placed on Injured List | | 6/14/2025 | Before |
| 6/14/2025 | NH | Blackburn | Promoted to active roster | | | Before |
| 6/15/2025 | BIW | Goodman | Demoted to reserve roster | | | Before |
| 6/15/2025 | BIW | Wong | Activated from Injured List | | | Before |
| 6/15/2025 | CB | Moreno | Placed on Injured List | | 6/15/2025 | Before |
| 6/15/2025 | CB | Noel | Promoted to active roster | | | Before |
| 6/15/2025 | MAR | Jimenez,E | Demoted to reserve roster | | | Before |
| 6/15/2025 | MAR | Raley,L | Activated from Injured List | | | Before |
| 6/15/2025 | WAN | Soroka | Promoted to active roster | | | Before |
| 6/15/2025 | WAN | Steele | Placed on Injured List | | 6/15/2025 | Before |