| Transactions |
| Date | Team | Player | Type | OthTm | EffDate | When |
| 3/29/2025 | LFK | Crews | Demoted to reserve roster | | | Before |
| 3/29/2025 | LFK | Waldron | Promoted to active roster | | | Before |
| 3/29/2025 | MIL | Hill,D | Demoted to reserve roster | | | Before |
| 3/29/2025 | MIL | Nido | Promoted to active roster | | | Before |
| 3/29/2025 | MPS | Chafin | Promoted to active roster | | | Before |
| 3/29/2025 | MPS | Freeman,T | Demoted to reserve roster | | | Before |
| 3/30/2025 | DAY | Perez,M | Demoted to reserve roster | | | Before |
| 3/30/2025 | DAY | Perez,M | Promoted to active roster | | | Before |
| 3/30/2025 | DAY | Rojas,Joh | Demoted to reserve roster | | | Before |
| 3/30/2025 | DAY | Wade,T | Promoted to active roster | | | Before |
| 3/30/2025 | MIL | Hill,D | Promoted to active roster | | | Before |
| 3/30/2025 | MIL | Nido | Demoted to reserve roster | | | Before |
| 3/30/2025 | PIP | Larnach | Placed on Injured List | | 3/30/2025 | Before |
| 3/30/2025 | PIP | Thomas,A | Promoted to active roster | | | Before |
| 3/31/2025 | BAB | Nelson,R | Promoted to active roster | | | Before |
| 3/31/2025 | BAB | Taillon | Placed on Injured List | | 3/31/2025 | Before |
| 3/31/2025 | CB | Abbott | Placed on Injured List | | 3/31/2025 | Before |
| 3/31/2025 | CB | Armstrong | Promoted to active roster | | | Before |
| 3/31/2025 | DAY | Basso | Placed on Injured List | | 3/31/2025 | Before |
| 3/31/2025 | DAY | Kelly,Z | Promoted to active roster | | | Before |
| 3/31/2025 | SAV | McKinstry | Demoted to reserve roster | | | Before |
| 3/31/2025 | SAV | Wilson,B | Promoted to active roster | | | Before |
| 4/1/2025 | FIN | Criswell,C | Promoted to active roster | | | Before |
| 4/1/2025 | FIN | Quantrill | Placed on Injured List | | 4/1/2025 | Before |
| 4/1/2025 | MNT | Miller,E | Placed on Injured List | | 4/1/2025 | Before |
| 4/1/2025 | MNT | Rogers,Tr | Promoted to active roster | | | Before |
| 4/2/2025 | LE | Bednar | Released | | | Before |
| 4/2/2025 | LE | Rice | Signed | | | Before |
| 4/3/2025 | BIW | Nola | Placed on Injured List | | 4/3/2025 | Before |
| 4/3/2025 | BIW | Verlander | Promoted to active roster | | | Before |
| 4/3/2025 | DAY | Rojas,Joh | Promoted to active roster | | | Before |
| 4/3/2025 | DAY | Wade,T | Demoted to reserve roster | | | Before |
| 4/5/2025 | BIW | Baldwin | Signed | | | Before |
| 4/5/2025 | BIW | Matz | Released | | | Before |
| 4/5/2025 | MPS | Chafin | Demoted to reserve roster | | | Before |
| 4/5/2025 | MPS | Freeman,T | Promoted to active roster | | | Before |
| 4/5/2025 | WAN | Suwinski | Promoted to active roster | | | Before |
| 4/5/2025 | WAN | Urias,L | Placed on Injured List | | 4/5/2025 | Before |
| 4/6/2025 | LFK | Crews | Promoted to active roster | | | Before |
| 4/6/2025 | LFK | Waldron | Demoted to reserve roster | | | Before |
| 4/6/2025 | WAN | Chargois | Placed on Injured List | | 4/6/2025 | Before |
| 4/6/2025 | WAN | Soroka | Promoted to active roster | | | Before |
| 4/7/2025 | COO | Feltner | Promoted to active roster | | | Before |
| 4/7/2025 | COO | Sears | Placed on Injured List | | 4/7/2025 | Before |
| 4/7/2025 | MAR | Jimenez,E | Promoted to active roster | | | Before |
| 4/7/2025 | MAR | Solano | Placed on Injured List | | 4/7/2025 | Before |
| 4/7/2025 | NH | Baz | Placed on Injured List | | 4/7/2025 | Before |
| 4/7/2025 | NH | Blackburn | Promoted to active roster | | | Before |
| 4/8/2025 | BIW | Goodman | Promoted to active roster | | | Before |
| 4/8/2025 | BIW | Wilson,Ja | Demoted to reserve roster | | | Before |
| 4/8/2025 | SAV | McKinstry | Promoted to active roster | | | Before |
| 4/8/2025 | SAV | Wilson,B | Demoted to reserve roster | | | Before |
| 4/9/2025 | WAN | Meadows | Placed on Injured List | | 4/9/2025 | Before |
| 4/9/2025 | WAN | Rocchio | Promoted to active roster | | | Before |
| 4/10/2025 | ALP | Imanaga | Placed on Injured List | | 4/10/2025 | Before |
| 4/10/2025 | ALP | Megill,Ty | Promoted to active roster | | | Before |
| 4/10/2025 | BIW | Dana | Released | | | Before |
| 4/10/2025 | BIW | Paris | Signed | | | Before |
| 4/11/2025 | BIW | Goodman | Demoted to reserve roster | | | Before |
| 4/11/2025 | BIW | Wilson,Ja | Promoted to active roster | | | Before |
| 4/11/2025 | CB | Friedl | Promoted to active roster | | | Before |
| 4/11/2025 | CB | Vierling | Placed on Injured List | | 4/11/2025 | Before |
| 4/11/2025 | GV | Jansen,D | Promoted to active roster | | | Before |
| 4/11/2025 | GV | Story | Demoted to reserve roster | | | Before |
| 4/11/2025 | ROL | Mize | Placed on Injured List | | 4/11/2025 | Before |
| 4/11/2025 | ROL | Morel | Released | | | Before |
| 4/11/2025 | ROL | Sammons | Signed | | | Before |
| 4/12/2025 | MAR | Alvarez,Y | Placed on Injured List | | 4/12/2025 | Before |
| 4/12/2025 | MAR | Trevino | Promoted to active roster | | | Before |
| 4/13/2025 | CB | Ahmed | Promoted to active roster | | | Before |
| 4/13/2025 | CB | Turner,J | Placed on Injured List | | 4/13/2025 | Before |
| 4/13/2025 | MIL | Correa | Placed on Injured List | | 4/13/2025 | Before |
| 4/13/2025 | MIL | Fairchild | Promoted to active roster | | | Before |
| 4/13/2025 | MIL | Liberatore | Demoted to reserve roster | | | Before |
| 4/13/2025 | MIL | Sewald | Promoted to active roster | | | Before |
| 4/13/2025 | NP | De La Cruz,E | Placed on Injured List | | 4/13/2025 | Before |
| 4/13/2025 | NP | Norby | Promoted to active roster | | | Before |
| 4/14/2025 | WAN | Chivilli | Promoted to active roster | | | Before |
| 4/14/2025 | WAN | Miller,Br | Placed on Injured List | | 4/14/2025 | Before |
| 4/15/2025 | BAB | Nelson,R | Demoted to reserve roster | | | Before |
| 4/15/2025 | BAB | Taillon | Activated from Injured List | | | Before |
| 4/15/2025 | CB | Abbott | Activated from Injured List | | | Before |
| 4/15/2025 | CB | Armstrong | Demoted to reserve roster | | | Before |
| 4/15/2025 | DAY | Basso | Activated from Injured List | | | Before |
| 4/15/2025 | DAY | Kelly,Z | Demoted to reserve roster | | | Before |
| 4/15/2025 | ROL | Drury | Placed on Injured List | | 4/15/2025 | Before |
| 4/15/2025 | ROL | Lee,B | Promoted to active roster | | | Before |
| 4/15/2025 | WEL | Civale | Promoted to active roster | | | Before |
| 4/15/2025 | WEL | Floro | Demoted to reserve roster | | | Before |
| 4/16/2025 | FIN | Criswell,C | Demoted to reserve roster | | | Before |
| 4/16/2025 | FIN | Quantrill | Activated from Injured List | | | Before |
| 4/16/2025 | SAV | Schwellenbach | Placed on Injured List | | 4/16/2025 | Before |
| 4/16/2025 | SAV | Wilson,B | Promoted to active roster | | | Before |
| 4/17/2025 | GV | Jansen,D | Demoted to reserve roster | | | Before |
| 4/17/2025 | GV | Story | Promoted to active roster | | | Before |
| 4/17/2025 | MNT | Miller,E | Activated from Injured List | | | Before |
| 4/17/2025 | MNT | Rogers,Tr | Demoted to reserve roster | | | Before |
| 4/17/2025 | WAN | Alexander,T | Promoted to active roster | | | Before |
| 4/17/2025 | WAN | Miller,T | Placed on Injured List | | 4/17/2025 | Before |
| 4/18/2025 | BIW | Lee,J | Promoted to active roster | | | Before |
| 4/18/2025 | BIW | Verlander | Demoted to reserve roster | | | Before |
| 4/18/2025 | EDI | Canha | Placed on Injured List | | 4/18/2025 | Before |
| 4/18/2025 | EDI | Carlson | Promoted to active roster | | | Before |
| 4/18/2025 | MNT | Miller,E | Placed on Injured List | | 4/18/2025 | Before |
| 4/18/2025 | MNT | Rogers,Tr | Promoted to active roster | | | Before |
| 4/18/2025 | SAV | Alonso | Placed on Injured List | | 4/18/2025 | Before |
| 4/18/2025 | SAV | Merrifield | Promoted to active roster | | | Before |
| 4/19/2025 | OWT | Margot | Promoted to active roster | | | Before |
| 4/19/2025 | OWT | Profar | Placed on Injured List | | 4/19/2025 | Before |
| 4/19/2025 | WAN | Meadows | Activated from Injured List | | | Before |
| 4/19/2025 | WAN | Rocchio | Demoted to reserve roster | | | Before |