| Transactions |
| Date | Team | Player | Type | OthTm | EffDate | When |
| 3/29/2025 | LFK | Crews | Demoted to reserve roster | | | Before |
| 3/29/2025 | LFK | Waldron | Promoted to active roster | | | Before |
| 3/30/2025 | PIP | Larnach | Placed on Injured List | | 3/30/2025 | Before |
| 3/30/2025 | PIP | Thomas,A | Promoted to active roster | | | Before |
| 3/31/2025 | BAB | Nelson,R | Promoted to active roster | | | Before |
| 3/31/2025 | BAB | Taillon | Placed on Injured List | | 3/31/2025 | Before |
| 4/1/2025 | MNT | Miller,E | Placed on Injured List | | 4/1/2025 | Before |
| 4/1/2025 | MNT | Rogers,Tr | Promoted to active roster | | | Before |
| 4/3/2025 | BIW | Nola | Placed on Injured List | | 4/3/2025 | Before |
| 4/3/2025 | BIW | Verlander | Promoted to active roster | | | Before |
| 4/5/2025 | BIW | Baldwin | Signed | | | Before |
| 4/5/2025 | BIW | Matz | Released | | | Before |
| 4/6/2025 | LFK | Crews | Promoted to active roster | | | Before |
| 4/6/2025 | LFK | Waldron | Demoted to reserve roster | | | Before |
| 4/7/2025 | COO | Feltner | Promoted to active roster | | | Before |
| 4/7/2025 | COO | Sears | Placed on Injured List | | 4/7/2025 | Before |
| 4/7/2025 | MAR | Jimenez,E | Promoted to active roster | | | Before |
| 4/7/2025 | MAR | Solano | Placed on Injured List | | 4/7/2025 | Before |
| 4/7/2025 | NH | Baz | Placed on Injured List | | 4/7/2025 | Before |
| 4/7/2025 | NH | Blackburn | Promoted to active roster | | | Before |
| 4/8/2025 | BIW | Goodman | Promoted to active roster | | | Before |
| 4/8/2025 | BIW | Wilson,Ja | Demoted to reserve roster | | | Before |
| 4/10/2025 | ALP | Imanaga | Placed on Injured List | | 4/10/2025 | Before |
| 4/10/2025 | ALP | Megill,Ty | Promoted to active roster | | | Before |
| 4/10/2025 | BIW | Dana | Released | | | Before |
| 4/10/2025 | BIW | Paris | Signed | | | Before |
| 4/11/2025 | BIW | Goodman | Demoted to reserve roster | | | Before |
| 4/11/2025 | BIW | Wilson,Ja | Promoted to active roster | | | Before |
| 4/11/2025 | GV | Jansen,D | Promoted to active roster | | | Before |
| 4/11/2025 | GV | Story | Demoted to reserve roster | | | Before |
| 4/12/2025 | MAR | Alvarez,Y | Placed on Injured List | | 4/12/2025 | Before |
| 4/12/2025 | MAR | Trevino | Promoted to active roster | | | Before |
| 4/15/2025 | BAB | Nelson,R | Demoted to reserve roster | | | Before |
| 4/15/2025 | BAB | Taillon | Activated from Injured List | | | Before |
| 4/15/2025 | WEL | Civale | Promoted to active roster | | | Before |
| 4/15/2025 | WEL | Floro | Demoted to reserve roster | | | Before |
| 4/17/2025 | GV | Jansen,D | Demoted to reserve roster | | | Before |
| 4/17/2025 | GV | Story | Promoted to active roster | | | Before |
| 4/17/2025 | MNT | Miller,E | Activated from Injured List | | | Before |
| 4/17/2025 | MNT | Rogers,Tr | Demoted to reserve roster | | | Before |
| 4/18/2025 | BIW | Lee,J | Promoted to active roster | | | Before |
| 4/18/2025 | BIW | Verlander | Demoted to reserve roster | | | Before |
| 4/18/2025 | EDI | Canha | Placed on Injured List | | 4/18/2025 | Before |
| 4/18/2025 | EDI | Carlson | Promoted to active roster | | | Before |
| 4/18/2025 | MNT | Miller,E | Placed on Injured List | | 4/18/2025 | Before |
| 4/18/2025 | MNT | Rogers,Tr | Promoted to active roster | | | Before |